Hippocrates comments on the "sacred" disease declaring that it is no more sacred than other diseases. He stresses the importance of the disease having no relation with the divine whatsoever, but instead being purely of human origin. The author of On the Sacred Disease argues that even the most mysterious of diseases was still of natural cause and not of divine origin.

On the Sacred Disease is a work of the Hippocratic Corpus, written in 400 BCE. The authorship of this piece can not be confirmed and is therefore regarded as dubious. The treatise is thought to contain one of the first recorded observations of epilepsy in humans. The author explains these phenomena by the flux of the phlegm flowing from the brain into the veins rather than assigning them a divine origin. This turn from a supernatural to a naturalistic explanation is considered a major break in the history of medicine.

Hippocrates (c. 460 – c. 370 BC), was a Greek physician of the Age of Pericles (Classical Greece), and is considered one of the most outstanding figures in the history of medicine. He is referred to as the father of western medicine in recognition of his lasting contributions to the field as the founder of the Hippocratic School of Medicine. Hippocrates is commonly portrayed as the paragon of the ancient physician, credited with coining the Hippocratic Oath, still relevant and in use today. He is also credited with greatly advancing the systematic study of clinical medicine, summing up the medical knowledge of previous schools, and prescribing practices for physicians through the Hippocratic Corpus and other works.