Ulysses' stream-of-consciousness technique, careful structuring, and experimental prose—full of puns, parodies, and allusions, as well as its rich characterisations and broad humour, made the book a highly regarded novel in the Modernist pantheon. In 1998, the Modern Library ranked Ulysses first on its list of the 100 best English-language novels of the 20th century. Joyce fans worldwide now celebrate 16 June as Bloomsday.

It was first serialised in parts in the American journal The Little Review from March 1918 to December 1920, and then published in its entirety by Sylvia Beach in February 1922, in Paris. It is considered to be one of the most important works of modernist literature, and has been called "a demonstration and summation of the entire movement". According to Declan Kiberd, "Before Joyce, no writer of fiction had so foregrounded the process of thinking." However, even proponents of Ulysses such as Anthony Burgess have described the book as "inimitable, and also possibly mad".

Joyce is best known for Ulysses (1922), a landmark work in which the episodes of Homer's Odyssey are paralleled in an array of contrasting literary styles, perhaps most prominent among these the stream of consciousness technique he utilized. Other well-known works are the short-story collection Dubliners (1914), and the novels A Portrait of the Artist as a Young Man (1916) and Finnegans Wake (1939). His other writings include three books of poetry, a play, occasional journalism, and his published letters.