The four focus areas of the Bone and Joint Decade are: Joint Disease, Osteoporosis, Back Pain and Skeletal Trauma. And you can see Joint Disease is really at the top of the list. Now why is that? Because it's one of the most common causes of physical disability around the world. And Osteoarthritis is the leading cause of Joint Disease worldwide. If we look at the general population the prevalence of Joint Diseases increases with age and you can see as people get older knee Osteoarthritis hip Osteoarthritis shoulder and hand Osteoarthritis increases with time.